Showing chemical card for S-methyl-5'-thioadenosine (CFc000337982)
Record Information
Version
1.0
Creation Date
Update Date
2022-09-14 05:32:09 UTC
Chemfont ID
CFc000337982
Molecule Identification
Common Name
S-methyl-5'-thioadenosine
Definition
5'-deoxy-5'-methylthioadenosine, also known as S-methyl-5'-thioadenosine or mta, is a member of the class of compounds known as 5'-deoxy-5'-thionucleosides. 5'-deoxy-5'-thionucleosides are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group. 5'-deoxy-5'-methylthioadenosine is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). 5'-deoxy-5'-methylthioadenosine can be found in a number of food items such as allspice, sesame, roselle, and bayberry, which makes 5'-deoxy-5'-methylthioadenosine a potential biomarker for the consumption of these food products. 5'-deoxy-5'-methylthioadenosine can be found primarily in blood and urine, as well as in human fibroblasts, platelet and prostate tissues. 5'-deoxy-5'-methylthioadenosine exists in all living species, ranging from bacteria to humans. In humans, 5'-deoxy-5'-methylthioadenosine is involved in a couple of metabolic pathways, which include methionine metabolism and spermidine and spermine biosynthesis. 5'-deoxy-5'-methylthioadenosine is also involved in several metabolic disorders, some of which include glycine n-methyltransferase deficiency, methionine adenosyltransferase deficiency, homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblg complementation type, and hypermethioninemia.
Belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group.
