Showing chemical card for GC-373 (CFc000329942)
| Record Information | |
|---|---|
| Version | 1.0 |
| Creation Date | 2022-09-06 19:45:53 UTC |
| Update Date | 2022-09-14 05:06:40 UTC |
| Chemfont ID | CFc000329942 |
| Molecule Identification | |
| Common Name | GC-373 |
| Definition | GC-373 is a peptide aldehyde which is metabolized from the bisulfide adduct, [GC-376 free acid][A219031,A219036]. It is an inhibitor of Mpro (otherwise known as 3CLpro), a viral encoded protease that cleaves and activates functional proteins involved in viral replication and transcription[A219036]. GC-373 has been shown to inhibit the Mpro target in various coronavirus strains, including feline, mink, and ferret Mpro [A219041]. Along with its prodrug, GC-376, GC-373 was recently investigated _in vitro_ in cell culture against SARS-Cov-2 Mpro [A219036]. The results showed potent inhibition of the target, suggesting that GC-373 holds therapeutic potential for Covid-19[A219036]. |
| Structure |  |
| Synonyms | Not Available |
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| CAS Registry Number | Not Available |
| SMILES | Not Available |
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| Chemical Taxonomy | |
| Classification | Not classified |
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| Physiological effect | Not Available |
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| Process | Not Available |
| Role | Not Available |
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| Predicted Properties | Not Available |
| External Links | |
| External Links | Not Available |
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| Synthesis Reference | Not Available |